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Introduction course

Open the doors to the fundamental perspectives of Clinical Psychoneuroimmunology.

A clinical science developed by Dr. Leo Pruimboom and more than 100 of his teachers. Designed for those wishing to acquire basic medical knowledge in the context of clinical psychoneuroimmunology.

Consist of

6 modules



Immerse yourself in the introductory course in Clinical Psychoneuroimmunology, cPNI. This course is recommended as initial preparation for the Postgraduate and Master’s Degree in Clinical Psychoneuroimmunology. It offers a comprehensive overview of the mechanisms and interrelationships of all body systems. Throughout the course, we will integrate biochemistry, physiology, biology, and anatomy within the framework of clinical PNI.


The course is divided into 6 modules, in total approximately 12 hours.

Module 1

Module 1

An introduction to the science and medicine of systems: Nutrigenomics and Nutrigenetics.
This module begins with a brief introduction to clinical psychoneuroimmunology in general, unravelling the mysteries of how the mind, body and immune system are intertwined.
Two fundamental issues in human health are explored: The impact of nutrition and malnutrition and how these challenges have created a genome and epigenome during the evolutionary process of Homo sapiens.
We will then delve into the exciting world of the impact of diet, exercise and rhythms on our overall health. We will discover how these elements shape our identity, affect our wellbeing and influence our behaviour. We will also explore the secrets of nutrigenomics and nutrigenetics, revealing how our food choices, exercise habits and lifestyle can directly influence the expression of our genes.
Culture has changed our context and modern life has a noticeable impact on our health by altering the communication between the biological systems that make up our bodies. Physiology and health depend on this communication between systems, so we begin this journey by exploring the different forms of communication through neuromessengers, cytokines and hormones.

Learning objectives
Student will:
• Learn clinical PNI as a science.
• Learn about the connection between different organs through hormones, neurotransmitters and cytokines.
• Understand PNI and begin to apply this knowledge to themselves and their area of expertise.

Module 3
Enzymes, hormones

Module 3

Metabolism is the basic system of life, so this module focuses on deepening our understanding of enzyme function and how we can manipulate it. We will explore catalysts and the factors that limit their efficiency, considering both the influence of chemistry, such as pH and cofactors, as well as physics, temperature, light and magnetic fields, on their functionality.


Energy distribution drives evolution and this process is facilitated by enzymes. In this module we will explore the vital importance of enzyme activity and how we can positively enhance it through exercise, diet and behavioural changes. B vitamins are essential for the development of life and act as cofactors for 31% of our enzymes. They are essential for energy production, metabolism and therefore the maintenance of life itself.

Neural and hormonal links are explored, highlighting the enormous influence of hormones on our behaviour, brain, immune system and flexibility. Hormones tell the story of a person’s life, reflecting the maturation of different biological systems and the biological adaptation to circadian and ultradian cycles. As such, they represent the rhythm of our health. In this module we will explore the types of hormones and the communication systems through the different types of receptors.

Learning objectives

Student will:

  • Understand how enzymes and hormones work.
  • Understand how exercise, diet and behavioural changes can influence enzyme function.
  • Know that: Everything is connected through neural and humoral pathways.
Module 4
Neurotransmitters and systemic medicine

Module 4

This module focuses on the study of the human connectome, deepening our understanding of neuromessengers and cytokines. Neuroimmunological communication, both at the neuronal and humoral level, is essential for maintaining homeostatic flexibility. We will also explore other messengers produced by specific tissues, such as adipokines, myokines and hepatokines. In humans, everything is interconnected and this interconnectedness is the basis of our amazing ability to adapt to contextual changes and interact with the environment.

What role do neurotransmitters play in communication between the brain, immune system, society and genes? How does stress affect the immune system? Throughout this module we will explore how we can influence neurotransmitter function through exercise, diet, exposure to cold and behavioural changes depending on the emotions we are experiencing. We will also look at the importance of a holistic approach for people with multiple symptoms. We will look at the control of the autonomic nervous system and the importance of intermittent living. We will also discuss the need for an integrative global medicine that considers pandemics, people and their interactions. All of this knowledge will be applied as therapeutic strategies in clinical practice.

Learning objectives

Student will:

  • Understanding how neurological and immune transmitters work.
  • Know how to influence transmitter function through exercise, diet and behavioural changes.
  • Begin to approach their clients or patients using systemic strategies.
Scientific board

Pruimboom Institute is privileged to have a team composed of members representing the foremost experts in the field of KPNI clinical psychoneuroimmunology.

How can we help you?
Whether you’re interested in signing up for a course, or want to know more about KPNI, we would love to hear from you. Please allow up to 48 hours for us to get back to you.


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    Admission requirements

    There are not entry requirements for this course.

    Consist of

    6 modules of approximately 2 hours each.

    Study load

    5 ECTS


    Online self-study.

    Teaching materials

    All teaching materials are offered in digital format. Consists of 1 video of about 2 hours and approximately 40 scientific articles per module.


    During the course you will have access to the private section of your campus website, where you can see the videos and download the articles. Once enrolled, you can start immediately. Videos are available for 3 months and can be watched at your own pace.


    Dr. Leo Pruimboom

    Examination / completion of training

    It is not mandatory to participate in the exams, but it is compulsory if you want to obtain the diploma. This course has an exam of 24 multiple-choice questions if you wish to obtain the diploma. If you do not wish to take the exam, you will receive a certificate of attendance. You will receive an email invitation to the exam after 3 months.

    Didactic development and content of the course

    Pruimboom Institute and its scientific committee are responsible for the development of the master’s programme; the members of the committee are continuously working on the program to include the latest discoveries and every three months there is a committee meeting to update the course content. The committee is made up of Prof. Dr. Marion Raab, Prof. Dr. Frits Muskiet, Tom Fox, Daniel de la Serna, Itziar Hernández, and Dr. Leo Pruimboom.


    The course is taught in Spanish and Dutch. Please visit the campus that interests you.

    Prices and registration

    We kindly refer you to the campus of your interest for prices and registration options.

    Ready to begin your medical transformation?