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Become a therapist in Clinical Psychoneuroimmunology

A clinical science developed by Dr.Leo Pruimboom and more than 100 of his teachers. Designed for medical and paramedical practitioners with only one big purpose; to specialist-level therapists in Clinical Psychoneuroimmnulogy.

Consist of

12 modules



Modern life puts a huge burden on human health, and this affects almost every single person. It is full of so-called Anthropocene risk factors that are entirely new for our immune system and cause multiple diseases, which can affect individuals for more than 40 years of their lifetime. Sitting time, environmental pollution and even artificial light are risk factors that cause possible disease in all of us. Furthermore, in these times humans are also always doing something; this is something entirely new, causing burnout in probably 40% of the world population by 2040. We can’t continue like this, and that is why you need to become a therapist in Clinical Psychoneuroimmunology. The science, or perhaps even philosophy, which aims not only at the recovery of health but also the increase of stress tolerance by using both existing effective whole-body interventions, as well as developing new ones. Today you cannot treat everyone with biomedical interventions. Humans suffer from maladies caused by toxic emotions, toxic thoughts, sleep disturbances and even unknown dangers. All those factors produce a low-grade inflammation that precedes most, if not all, chronic diseases, including the susceptibility to possibly pandemic viral infections. Low-grade inflammation is treatable, and so are all the diseases as its consequence.

If you are a medical or paramedical practitioner of the 21st century, you need to be ‘integrative’. So don’t miss out on this opportunity to learn clinical psychoneuroimmunology, and become a Clinical Psychoneuroimmunologist.

Why should I study Clinical Psychoneuroimmunology?

You will receive the most up-to-date training in the field of clinical psychoneuroimmunology

You will be empowered to offer truly comprehensive care to your patients and clients, addressing not just the symptoms, but also the underlying causes of pathologies

You will have access to our full library of resources, a team of dedicated professionals, and the combined expertise of our growing community

“We recommend this course to anyone who is ready to advance their clinical practice to the next stage. Medical practitioners of all disciplines, as well as their patients, can benefit from this innovative medical approach.”

Leo Pruimboom – Director of the Pruimboom Institute


The course is divided into six modules per year, each covering a different topic in KPNI.

Module 2
Evolutionary medicine

Module 2

This module deals with the evolutionary aspects that have made humans, plants and other living things what we are today. Older known anthropogenic stressors such as infection, hunger, thirst and climate change have led to innumerable adaptations in the field of our genome and in the way the genome functions (the epigenome).

New risk factors such as sedentary life, eating 6 times a day, mortgage stress and many other factors are so new to the genetically “old: homo sapiens” that our health controller (read hypothalamus) has not (yet) found a solution for them. These new stressors cause a conflict with our genome, which is full of polymorphisms meant to survive under previous conditions; the same polymorphisms, along with epimutations, are now the cause of most if not all chronic diseases suffered by modern humans, especially in the wealthy West, so those diseases can be considered evolutionary scars.

Genetics, epigenetics, polymorphisms and evolutionary stressors are the topics of the first day. The second day deals with “how it works” and “why it works this way”, the most important questions within evolutionary clinical PNI. The third day translates all evolutionary knowledge into certain interventions in a number of very common conditions.

Learning objectives

Student will:

  • Look at clients from the point of view of why they function the way they do, from an evolutionary perspective.
  • Learn the evolutionary mechanisms of action responsible for diseases today and use the tools to reset these mechanisms in patients.
  • Identify diseases as evolutionary scars and use evolutionary interventions to treat people suffering from these conditions.
  • Discover the meaning of the concept of Intermittent Living and apply a number of the interventions in your own life.
  • Learn to identify the evolving mechanism of action that the “error” is utilized by a patient (e.g., insulin resistance and cortisol resistance).
  • Be presented with a list of functional parameters that allow them to identify a disorder of an evolving mechanism of action.
Module 3

Module 3

This module explores how our body has learned to respond to homeostatic changes (i.e. stress) and how that response can either protect us or make us sick. The first day is dedicated to the sympathizer and the HPA axis. The remaining two days are dedicated to all the other axes that come from the homeostatic regulatory organ of all living animals on earth: the hypothalamus.

Stress is much more than a psycho-emotional burden. Factors such as changing ambient temperature, eating too often and lack of sleep are also stressors and require a reaction from one or more axes of the hypothalamus. Again, evolution will play an important role within this module, as our hypothalamus has remained almost identical over the last 250 million years, it means that modern life is very “foreign” to this organ.

Learning objectives

Students will:

  • Learn about the difference between homeostasis and allostasis is used to identify hypothalamic axis disorders.
  • Analyze the function of the hypothalamus using validated measurement instruments and functional parameters.
  • Learn to treat clients with universal inflammation of the hypothalamus, as it is the cause of most, if not all, chronic non-infectious diseases.
  • Use the concepts of physical and mental stress to guide clients with specific interventions.
  • Learn to use a number of tests to determine patients’ response to stress: the Trier Social Stress Test, the neuroglycopenia test, the autonomic reaction test, the cold stress test (CST) and the Maastricht associated stress test (MAST).
Module 7
The selfish immune-system

Module 7

This module integrates the first six modules of the first year of study through the concept of selfish organs, namely the selfish brain, the selfish immune system and the selfish metabolic system. We will discuss the strategies that have been used so far to maintain the various systems both anatomically and functionally.

Normally, the three systems should work together in harmony, whereas this cooperation is disturbed in people suffering from chronic diseases. The way one of the systems takes over dominance leads to certain disorders that are also known as selfish brain disorder, selfish immune system disorder or selfish metabolic system disorder. In addition, the methodology used to map disorders of the three systems will be discussed in depth.

A number of disorders, including Hashimoto’s, depression and burnout, will be specifically discussed using the five metamodels. From this module you will assume the role of therapist and treat at least three real patients. These patients are pre-selected for their complexity, which makes it possible for students to attempt to arrive at a diagnosis and treatment. In addition, the reproductive system has recently been introduced as selfish. Therefore, the HPG axis plays an important role in the last day of this module. Premenstrual syndrome and other disorders of the HPG axis are discussed both theoretically and practically and completed with a therapeutic protocol.

Learning objectives

Students will:

  • Learn the three super-systems and the most common syndromes based on the clinical-chemical and functional parameters to which they belong.
  • Treat patients by influencing one or more super-systems.
  • Learn to use the five metamodels in the context of treating real patients.
Scientific board

Pruimboom Institute is privileged to have a team composed of members representing the foremost experts in the field of KPNI clinical psychoneuroimmunology.

How can we help you?
Whether you’re interested in signing up for a course, or want to know more about KPNI, we would love to hear from you. Please allow up to 48 hours for us to get back to you.


    I want to know more
    Admission requirements

    Admission to the course requires a complete medical or paramedical education. In addition, persons with a complete education in basic medical knowledge at higher professional education level or in basic medical subjects, plus training in orthomolecular therapy, are admitted. Individuals who are athletes, who have undergone recognized personal trainer training or who have completed osteopathic training may also enroll.


    Accredited by PNI Europe.

    Master of the University of Salamanca

    The course is two years long, plus an optional third year. Individuals who pass the theoretical exam at the end of the first year, and the practical exam at the end of the second year are entitled to use the title of “therapist in KPNI”.

    The third year entitles you to the title of “Master in KPNI” of the University of Salamanca (Universidad Pontificia de Salamanca) upon successful completion (see exam procedure).

    The master’s year exam consists of a 50-question multiple-choice exam + two portfolio papers during the training year.

    This master’s degree is organized by the University in collaboration with PNI Europe and is valid worldwide.

    For more information, see the Master’s degree.

    Consist of

    Two academic years, 12 modules. Each of the academic courses consists of 6 three-day seminars and Q & A sessions.

    Study load

    40 ECTS

    Number of places

    Approximately 45 students per class, but the amount may vary depending on the campus.


    Online, live virtual and in-person.

    Teaching materials

    All teaching materials are offered in digital format. In each module, students will receive:

    • A digital reference text supporting the topics covered in that module
    • Digital didactic material
    • Scientific articles

    During the course you will have access to the private section of your campus website, where you can download all presentations, articles and supporting chapters. There is also a student auditorium (digital library) and an interactive forum.During the course you will have access to the private section of the PNI Europe website, where you can download all presentations, articles and supporting chapters. There is also a student auditorium (digital library) and an interactive forum.

    Examination / completion of training

    It is not mandatory to participate in the exams. If the student has taken at least 80% of all classes, he/she will receive a certificate of participation. If you wish to take the exam, you can register via a registration form. The exam is subject to PNI Europe guidelines, which can be found on the PNI Europe website. To take the exam, the student must have completed 80% of all modules. The costs of the exams are indicated on the website.

    The exams consist of both written and practical parts. Once the exams are passed, the title “Therapist in Clinical Psychoneuroimmunology” can be used.

    Failure to pass the Year 1 and Year 2 exams has no consequences, and the student can apply to retake the exam at a later time. If you fail one of these exams, you can still continue with the course. To be eligible for the master’s year, the student must pass all exams. You can also start the master’s degree if you have requested to retake one of the exams.

    Didactic development and content of the master

    Pruimboom Institute and its scientific committee are responsible for the development of the master’s programme; the members of the committee are continuously working on the program to include the latest discoveries and every three months there is a committee meeting to update the course content. The committee is made up of Prof. Dr. Marion Raab, Prof. Dr. Frits Muskiet, Tom Fox, Daniel de la Serna, Itziar Hernández, and Dr. Leo Pruimboom.

    Organisation chart

    The master’s is taught by Pruimboom institute teachers and/or by teachers from Pruimboom Institute partners at the different campuses. The University of Salamanca is in charge of granting the diplomas that certify the title of Master in Clinical Psychoneuroimmunology.

    Prices and registration

    We kindly refer you to the campus of your interest for prices and registration options.

    Ready to begin your medical transformation?